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Title   임파절전이가 없는 유방암의 예후인자 ( Prognostic Factors in Node - Negative Breast Cancer )
Publicationinfo   1995 Jan; 027(02): 265-275.
Key_word   Node, Breast cancer, Prognostic factors
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Abstract   Breast cancer is the third most common malignant neoplasm in Korean women. The effect of postoperative adjuvant systemic therapy in the treatment of primary breast cancer with pathologic involvement of the axillary lymph nodes has been well established. But, 20 30% of node-negative breast cancer patients will develop recurrent disease and risk death within 10 years after initial local therapy without adjuvant treatment. Therfore, it is reasonable to identify those node-negative breast cancer patients at significant risk for recurrence and who could be treated with adjuvant therapies. A clinical study was perofrmed in 184 cases of primary node-negative breast cancers from January 198l to December 1991 to study the natural course of the diaease and to find-out the prognostic factors. The following results were obtained; l) During 73 monthe(9-143) of follow-up duration, 5-year and 10-year relapse free survival rates were 88%, 77% respectively, and overall survival rates were 89%, 88%, respectively. 10 year recurrence rate was 19%. 2) Median disease-free and survival durations were 80 month, 17 months, respectively, in tumor size<2 cm group and 68.5 months, 62 months respectively in tumor size 2-5 cm group. 3) Median disease-free and overall survival durations were 73 months, 61 months, respectively, in premenopause patients and 74 months, 73 months in postmenopause patients. 4) No differences were found in disease-free and survival duration based on types of operation. 5) With adjuvant treatment, there was a decreasing tendency of systemic relapse. In conclusion, continuous relapse was found in node-negative breast cancer even after 5 years of operation. Even if decreasing tendency of systemic relapse was induced with adjuvant treatment, no clinically useful prognostic factors were found from surgical and pathologic factors until now. Further study of biological factors in node-negative breast cancer is warrented.
저 자   이경희(Kyung Hee Lee),정현철(Hyun Cheol Chung),조재용(Jae Yong Cho),라선영(Sun Young Rha),안중배(Joong Bae Ahn),이종인(Chong In Lee),유내춘(Nae Choon Yoo),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),김병수(Byung Soo Kim),이경식(Kyung Sik Lee),이기범(Kyl Beom Lee),임호영(Ho Yeong Lim),최진혁(Jin Hy